The powerhouse of the cell, mitochondria play several cellular functions, and it also regulates the physiological adjustment of the body. The deregulation of any of the key factors in the regulation pathway of energy production or cellular metabolism leads to disease conditions and, sometimes even cancer. Several studies emphasize the fact that the alteration in metabolic pathways, generate or evoke cancer susceptibility including breast cancer. Among the several cancers, breast cancer is a major concern in the female population. Thus, the alteration of any mitochondrial factors or metabolites associated with the mitochondrial energy cycle, the changes in breast cancer development or progression of metastasis is high. Mitochondrial regulation could be a promising therapeutic approach in the treatment of breast cancer.