Design considerations for the metallic nanoparticles for biosensing were introduced firstly. Then the
commonly used nanofabrication approaches were presented. After that, one important application, localized surface
plasmon polritons (LSPR)-based immunoassay using the nanoparticles array was illustrated. Finally, the LSPR-related
photothermal therapy was briefly described.
Metallic nanoparticles array being used as sensors for biosensing is a major application of nanophotonic devices,
especially for the localized surface plasmon resonant (LSPR) effect-based nano-biosensors. It is an important approach
for immunoassay. Numerous biosamples can be detected by means of the LSPR-based nano-biosensors such as biotin,[1]
amyloid-derived diffusible ligands,[2] and Staphylococcus aureus enterotoxin B etc.[3] It becomes appealing for
biological researchers due to its advantages of portable, cost effective, light weight, small volume, and simple system in
comparison to the conventional SPR system, e.g., Bicore system.
