Currently, Ti-Mo, Ti-Nb, Ti-Ta and Ti-Zr-based β-titanium alloys have been widely studied. Compared with other titanium alloys, these alloys can achieve lower elastic modulus and higher strength. Since Ti-Nb alloy has low elastic modulus and good shape memory effect, it is the most promising medical titanium alloy to develop and utilize. Beta titanium alloys with the elements of Nb,Ta,Zr are being studied as the most important biomedical materials. This chapter presents the microstructure and mechanical properties of TiNbTaZr titanium alloy. The results show that the TiNbTaZr β titanium alloy with lower elastic modulus and non-toxic alloying elements has much more important application in biomedical field. The Ti35Nb2Ta3Zr β titanium alloy is studied and the alloy has the complex properties of lower elastic modulus, high strength, high elongation and excellent shape memory effect. Compared with direct rolling, cross rolling is beneficial to the isotropic of the microstructure and mechanical properties.