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Central Nervous System Agents in Medicinal Chemistry

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ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

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Research Article

Pharmacological Approach of Pistacia Vera Fruit to Assess Learning and Memory Potential in Chemically-Induced Memory Impairment in Mice

Author(s): Satyam Singh, Dharamveer and Mayank Kulshreshtha*

Volume 19, Issue 2, 2019

Page: [125 - 132] Pages: 8

DOI: 10.2174/1871524919666190304122927

Price: $65

Abstract

Objective: The present study was designed to investigate the potential of Pistacia vera (P. vera) fruits in experimental memory impairments in mice.

Material & Methods: Memory impairment was induced in Swiss Albino mice by scopolamine (0.4mg mg/kg. i.p). Animals were divided into five separate groups of six animals each, positive control group received carboxy methyl cellulose (CMC) as vehicle, negative control group received scopolamine with vehicle, and standard group received donepezil (5mg/kg i.p) with Scopolamine. Ethanolic extract of P. vera (EEPV) at doses of 200mg/kg & 400mg/kg p.o were administered to group test1 & test 2 respectively along with scopolamine. Elevated plus maze (EPM), passive avoidance paradigms and morris water maze (MWM) were used as exteroceptive behavioral models to access learning and memory activity. Transfer latency, step down latency and escape latency parameters were evaluated plus maze, passive avoidance paradigm, morris water maze. Thereafter lipid peroxidation test, glutathione level and catalase activities were estimated in homogenized brain of mice.

Results: Pretreatment of mice with EEPV (200mg/kg & 400mg/kg) significantly reduced scopolamine induced amnesia. The obtained data clearly revealed that there was increase in escape latency in MWM and also increase in step down latency in passive avoidance paradigm. Transfer latencey was found to be decrease in EPM and biochemical. Parameters were clearly satisfied the data as compared to negative control group which was indicative of cognitive improvement.

Conclusion: P. vera fruit extract demonstrated to improve cognitive process by enhancing memory in different experimental paradigm such as EPM, passive avoidance and MWM when administered orally. Hence it would be worthwhile to explore the potential of this plant in the management of memory disorders.

Keywords: Alzheimer's disease, Pistacia vera, flavonoids, memory, memory disorders, scopolamine.

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Graphical Abstract

[1]
Thalla, S.; Tammu, J.; Pentela, B.; Thalla, R.S. Nootropic activity of Asteracantha longifolia in streptozotocin induced amnesia. IJCPS, 2012, 3(1), 70-73.
[2]
Bhattacharjee, A.; Shashidhara, C.S.; Saha, S. Nootropic activity of Crataeva nurvala Buch-Ham against scopolamine induced cognitive impairment. EXCLI, 2015, 14, 335-345.
[3]
Kumar, R.; Kumar, V.R.; Kumar, V.P.; Kumar, V.; Swaminaidu, V.P. A review on amnesia. Int. J. Allied. Med. Sci. Clin. Res, 2013, 1, 34-37.
[4]
Nahida, A.S.H.; Siddiqui, A.N. Carried review on phytochemical and pharmacological property on Pistacia lentiscus. J. Pharm. Pharm. Sci., 2012, 4(4), 16-20.
[5]
Mohannad, G.; Saghir, A.L.; Porter, D.M. Taxonomic revision of the genus Pistacia. AJPS, 2012, 3(12), 32-33.
[6]
Aslan, M.; Orhan, I. Fatty acid patterns of waste parts of Turkish Pistacia vera tree. Acta. Biol. Cracov. Bot., 2006, 48(2), 117-120.
[7]
Orhan, I.; Kupeli, M.; Aslan, M.; Yesilada, E. Bioassay guided evaluation of anti-inflammatory and antinociceptive activities of Pistacia vera. J. Ethnopharmacol., 2006, 105, 235-240.
[8]
Sujith, K.; Darwin, R.C.; Sathish, S.V. Memory enhancing activity of Anacyclus Pyrethrum in Albino wistar rats. Asian Pac. J. Trop. Dis., 2012, 2(4), 307-311.
[9]
Yadav, C.Y. Jain. A.; Deb. L. A review: Neuropharmacological screening techniques for pharmaceuticals. IJPPS, 2010, 2(2), 11-14.
[10]
Jyoti, G.; Mayank, K. pharmacological investigation and unraveling mechanism of action of Jasminum sambac flowers for predicated treatment of alzheimer’s disease. Curr. Nutr. Food Sci., 2017, 13, 1-8.
[11]
Allami, N.; Payda, M.J.; Rayatnia, F.; Sehhat, K.; Rahimian, R.; Norouzi, A.; Dehpour, A.R. Suppression of nitric oxide synthesis by L-NAME reverses the beneficial effects of pioglitazone on scopolamine-induced memory impairment in mice. Eur. J. Pharmacol., 2011, 650, 240-248.
[12]
Joshi, H.; Parle, M. Effects of piperine on memory and behavior mediated via monoamine neurotransmitters. J. Trad. Med., 2005, 2, 39-43.
[13]
Khare, P.; Yadav, G.; Chaudhary, S.; Singh, L. Investigation on protective effect of Cressa cretica extract in scopolamine induced memory impairment. IJPT, 2014, 2(1), 13-16.
[14]
Narwal, S.; Saini, R.D.; Kumari, K.; Narwal, S.; Singh, G. Behavior & pharmacological animal models for the evaluation of learning & memory condition. Indo Glob. J. Pharm., 2012, 2(2), 121-129.
[15]
Kulkarni, D.P.; Ghaisas, M.M.; Chivate, D.N.; Sankpal, S.P. Memory enhancing activity of Cissampelos pariera in mice. Int. J. Pharm. Pharm. Sci., 2011, 3(2), 206-211.
[16]
Kunte, B.K.; Kuna, Y. Neuroprotective role of Bacopa Monniera extract (BME) on monoamine oxidase in AD induced mice with particular reference to morphometric and behavioural aspects. JIARM, 2014, 2(1), 590-600.
[17]
Biradar, S.M.; Joshi, H.; Chheda, T.K. Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of alzheimer’s disease. Eur. J. Pharmacol., 2012, 683, 140-147.
[18]
Nagakannan, P.; Shivasharana, D.B.; Thippeswamy, S.B.; Veerapu, P.V.; Bansal, P. Protective effect of hydroalcoholic extract of Mimusops elengi flowers against middle cerebral artery occlusion induced brain injury in rats. J. Ethnopharmacol., 2012, 140, 247-254.
[19]
Ghadrdoost, B.; Vafaei, A.A.; Pour, R.A.; Hajisoltani, R. Protective effects of saffron extracts and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. Eur. J. Pharmacol., 2012, 667, 222-229.
[20]
Baitharu, I.; Jain, V.; Deep, S.N.; Hota, K.B.; Hota, S.K.; Prasad, D.; Ilavazhagan, G. Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats. Neuropharmacology, 2013, 64, 65-73.
[21]
Kulkarni, D.P.; Ghaisas, M.M.; Chivate, D.N.; Sankpal, S.P. Memory enhancing activity of Cissampelos pariera in mice. Int. J. Pharm. Pharm. Sci., 2011, 3(2), 206-211.
[22]
Kumar, R.; Kumar, V.R.; Kumar, V.P.; Kumar, V.; Swaminaidu, V.P. A review on amnesia. Int. J. Allied. Med. Sci. Clin. Res., 2013, 1, 34-37.
[23]
Gupta, J.; Kulshreshtha, M. Memory impairment with reference to alzheimer’s disease: An update. Int. J. Nutr. Pharmacol. Neurol. Dis., 2017, 7, 45-53.
[24]
Evans, W.C.; Evans, D.; Trease, G.E. Trease and Evan’s pharmacognosy, 16th ed; Saunders/Elsevier: USA, 2009.
[25]
Jamdhade, C.V.; Surwase, S.B. Memory enhancing activity of Taverniera cuneifolia (Roth) ARN: A substitute for commercial liquorice. Int. J. Pharma Bio Sci., 2013, 4(2), 277-285.
[26]
Khare, P.; Yadav, G.; Chaudhary, S.; Singh, L. Investigation on protective effect of Cressa cretica extract in scopolamine induced memory impairment. IJPT, 2014, 2(1), 13-16.
[27]
Ozarowski, M.; Mikolajczak, L.P.; Bogacz, A.; Gryszczynska, A.; Kujawska, M. Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. Fitoterapia, 2013, 91, 261-271.
[28]
Nontamart, N.; Tongjaroenbuangam, W.; Srisawat, R. The memory enhancing effects of the extract from the fruit hull of Mangosteen (Garcinia mangostana L) in healthy adult male rats. IPCBEE, 2013, 55(22), 117-121.
[29]
Ghadrdoost, B.; Vafaei, A.A.; Pour, R.A.; Hajisoltani, R. Protective effects of saffron extracts and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. Eur. J. Pharmacol., 2012, 667, 222-229.
[30]
Nagakannan, P.; Shivasharana, D.B.; Thippeswamy, S.B.; Veerapu, P.V.; Bansal, P. Protective effect of hydroalcoholic extract of Mimusops elengi flowers against middle cerebral artery occlusion induced brain injury in rats. J. Ethnopharmacol., 2012, 140, 247-254.
[31]
Rajasekar, N.; Dwivedi, S.; Tota, K.S.; Kamat, K.P.; Hanif, K.; Nath, C.; Shukla, R. Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice. Eur. J. Pharmacol., 2013, 715, 381-394.
[32]
Manal, F.; Khadragy, E.L.; Ebtesam, M.; Olayan, A.L.; Ahmed, E.; Moneim, A. Neuroprotective effects of citrus reticulata in scopolamine-induced dementia oxidative stress in rats. CNS Neurol. Disord. Drug Targets, 2014, 13, 684.
[33]
Stewart, R. Herbalism Most common form of medicine available. East. Pharm., 1997, 475, 21.
[34]
Dinesh, K.C. Pharmacognosy can help minimize accidental misuse of herbal medicine. Curr. Sci., 2007, 3, 1356-1358.
[35]
Guidelines for the assessment of herbal medicines programme on traditional medicine, Geneva: World Health Organization, document, 1991 1991.(WHO/TRM/91.4).
[36]
Thomas, S.C. Medicinal plants culture, utilization and phytopharmacology, 2nd ed; CRC Press: USA, 1995.

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