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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Regulation of T cell Apoptosis during the Immune Response

Author(s): Sven Baumann, Andreas Krueger, Sabine Kirchhoff and Peter H. Krammer

Volume 2, Issue 3, 2002

Page: [257 - 272] Pages: 16

DOI: 10.2174/1566524024605671

Price: $65

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Abstract

Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response.

Keywords: T cell Apoptosis, Immune Response, CD95 SIGNALING PATHWAY, THYMOCYTE SELECTION, DEATH RECEPTORS, Death domain, FLICE inhibitory protein


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