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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Biological Activities of Artemisinin Derivatives Beyond Malaria

Author(s): Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen

Volume 19, Issue 3, 2019

Page: [205 - 222] Pages: 18

DOI: 10.2174/1568026619666190122144217

Price: $65


Artemisinin is isolated from Artemisia annua L. with peroxide-containing sesquiterpene lactone structure. Because of its unique structural characteristics and promising anticancer, antivirus activities, it has recently received increasing attention. The aim of this review is to summarize recent discoveries of artemisinin's novel derivatives with new pharmaceutical effects beyond malaria with a focus on its antitumor and antivirus activity, as well as potential results of combination therapy with other clinical drugs.

Keywords: Anticancer activity, Antiviral activity, Artemisinin, Artemisinin derivatives, Dimer, Trimer.

Graphical Abstract
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