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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Chemistry and Biological Activity of [1,2,3]-Benzotriazine Derivatives

Author(s): Ghodsi Mohammadi Ziarani*, Manizheh Mostofi and Negar Lashgari

Volume 22, Issue 28, 2018

Page: [2717 - 2751] Pages: 35

DOI: 10.2174/1385272822666181109123711

Price: $65


[1,2,3]-Benzotriazines represent an interesting category of heterocyclic compounds. Various synthetic methods, key reactions and biological aspects have been highlighted. In particular, some analogues have shown antitumor activity. [1,2,3]- Benzotriazin-4-one derivatives are applied extensively as herbicides, insecticides and nematicides. Incorporation of these compounds into the human food chain is a cause of concern, since their toxicity to man is well documented. This review is an attempt to discuss synthesis, chemical reactions, applications and pharmacological aspects of [1,2,3]- benzotriazine analogues from 1957 till date.

Keywords: [1, 2, 3]- Benzotriazines, [1, 2, 3]- BenzotriazineN-oxide, [1, 2, 3]- Benzotriazin-4(3H)-one, 4- Hydroxy- [1, 2, 3]-benzotriazines, coupling agent, HOOBt.

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