摘要
多倍体与细胞大小增加有关，并且通常存在于成人器官的子集和人胚胎的卵裂球阶段。 通过核内复制或细胞融合形成多倍体，以支持包括最早胚胎发生在内的特定发育需要。 最近的数据表明，多倍体巨细胞癌细胞（PGCCs）可能已经获得了一种活化的早期胚胎样程序，以响应致癌和治疗压力，从而产生用于药物抗性和转移的重编程癌细胞。 针对PGCC可能为癌症治疗开辟新的机会。
关键词: 多倍体巨细胞癌细胞，癌症干细胞，卵裂球样癌干细胞，核内复制，重编程，细胞融合。
图形摘要
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