Abstract
Background: Febrile neutropenia is one of the major acute side effects of intensive treatment in pediatric cancer, necessitating prompt initiation of empirical broad-spectrum antibiotics. Patients may be classified as low or high risk according some risk factors (duration of neutropenia, depth of neutropenia, type of cancer, state of disease, bone marrow involvement, type of treatment, additional health problems). Initial evaluation of the febrile neutropenic child should include the history of the child, a detailed physical examination, blood culture (peripheral and catheter), urinalysis and culture, cultures of lesions.
Result & Conclusion: The standard of care in febrile neutropenic children is that they should be hospitalized, especially if high risk, and should be treated urgently with intravenous wide spectrum empiric antibiotics, the spectrum covering P. Aeruginosa. Empiric treatment should be modified according to culture results and clinical situation. Other options for low risk patients are starting with intravenous treatment and continuing with per oral treatment or giving per oral antibiotic treatment from the beginning.
Keywords: Childhood cancer, febrile neutropenia, pediatrics, diagnosis, treatment, patients.
Current Pediatric Reviews
Title:Febrile Neutropenia in Children with Cancer: Approach to Diagnosis and Treatment
Volume: 14 Issue: 3
Author(s): Rejin Kebudi*Hande Kizilocak
Affiliation:
- Cerrahpasa Faculty of Medicine, Pediatric Hematology-Oncology, Istanbul University, Istanbul,Turkey
Keywords: Childhood cancer, febrile neutropenia, pediatrics, diagnosis, treatment, patients.
Abstract: Background: Febrile neutropenia is one of the major acute side effects of intensive treatment in pediatric cancer, necessitating prompt initiation of empirical broad-spectrum antibiotics. Patients may be classified as low or high risk according some risk factors (duration of neutropenia, depth of neutropenia, type of cancer, state of disease, bone marrow involvement, type of treatment, additional health problems). Initial evaluation of the febrile neutropenic child should include the history of the child, a detailed physical examination, blood culture (peripheral and catheter), urinalysis and culture, cultures of lesions.
Result & Conclusion: The standard of care in febrile neutropenic children is that they should be hospitalized, especially if high risk, and should be treated urgently with intravenous wide spectrum empiric antibiotics, the spectrum covering P. Aeruginosa. Empiric treatment should be modified according to culture results and clinical situation. Other options for low risk patients are starting with intravenous treatment and continuing with per oral treatment or giving per oral antibiotic treatment from the beginning.
Export Options
About this article
Cite this article as:
Kebudi Rejin*, Kizilocak Hande, Febrile Neutropenia in Children with Cancer: Approach to Diagnosis and Treatment, Current Pediatric Reviews 2018; 14 (3) . https://dx.doi.org/10.2174/1573396314666180508121625
DOI https://dx.doi.org/10.2174/1573396314666180508121625 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds
Mini-Reviews in Medicinal Chemistry Glycosphingolipid Structure and Function in Membranes
Current Organic Chemistry Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents
Current Medicinal Chemistry Drug Targeting to the Brain - A Review
Current Nanoscience Targeting Vascular Endothelial Growth Factor in Neuroblastoma
Current Angiogenesis (Discontinued) Metabolic Profiling in Disease Diagnosis, Toxicology and Personalized Healthcare
Current Pharmaceutical Biotechnology Calreticulin in the Heart: From Embryological Development to Cardiac Pathology.
Current Molecular Medicine From the Table to the Bedside: Can Food-Derived Sulforaphane be used as a Novel Agent to Treat Leukemia?
Current Cancer Drug Targets The Roles of Chromatin Remodeling Proteins in Cancer
Current Protein & Peptide Science Gap Junction Synthesis and Degradation as Therapeutic Targets
Current Drug Targets Anti-NMDA Receptor Encephalitis in Psychiatry
Current Psychiatry Reviews The Importance of Guidelines in the Development and Application of Probiotics
Current Pharmaceutical Design Inhibition of Membrane Fusion as a Target for Antiviral Therapy
Anti-Infective Agents in Medicinal Chemistry Cardiac Toxicity of Antineoplastic Anthracyclines
Current Medicinal Chemistry - Anti-Cancer Agents Heparanase as a Target in Cancer Therapy
Current Cancer Drug Targets Imaging Adoptive Cell Transfer Based Cancer Immunotherapy
Current Pharmaceutical Biotechnology Current Therapeutic Options for the Treatment of Juvenile Idiopathic Arthritis
Current Rheumatology Reviews Factors Modulating Chondrogenesis and Mechano-Inductive Systems for Cartilage Tissue Engineering from Mesenchymal Stem Cells: A Review
Current Tissue Engineering (Discontinued) Modulators of Networks: Molecular Targets of Arterial Calcification Identified in Man and Mice
Current Pharmaceutical Design A Novel Hydroxysteroid-Sulfating Cytosolic Sulfotransferase, SULT3 ST3, from Zebrafish: Identification, Characterization, and Ontogenic Study
Drug Metabolism Letters