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Current Biomarkers (Discontinued)


ISSN (Print): 2468-4228
ISSN (Online): 2468-4236

Research Article

Baseline Levels of Interleukine-6, Tumor-Necrosis Factor-Alpha and C-Reactive Protein in Treatment Naive Human Immunodeficiency Virus Infected Patients-A Study from a Tertiary-Care Hospital in Eastern India

Author(s): Anindita Debnath, Madhuchhanda Mandal, Sayantani Choudhuri, Malay K. Saha and Subhasish Kamal Guha*

Volume 6, Issue 2, 2016

Page: [124 - 132] Pages: 9

DOI: 10.2174/2468422807666170221122733

Price: $65


Background: Inflammatory cytokines play a major role in pathophysiology, prognosis and progression in HIV infection. Studies on pre-ART levels of different pro-inflammatory and coagulation markers have shown predictive role on progression and mortality in HIV. IL-6, CRP has also been shown to be correlated with HIV-RNA levels as disease progresses.

Objective: Biomarkers of inflammation are of increasing interest as predictors of morbidity and mortality in HIV infected patients. Though India is a major contributor to HIV-related mortality in Asia and Pacific zone, studies on inflammatory markers predictive of progression of HIV disease, on population from the Indian sub-continent are few. In this study, we observed the baseline levels of inflammatory cytokines among treatment naïve HIV positive subjects in respect to healthy volunteers.

Materials and Methods: Serum levels of IL-6, TNF-α and CRP in 130 antiretroviral naive, HIVpositive individuals were estimated using sandwich ELISA, along with routine CD4 cell count, plasma HIV-1 viral load and biochemical tests for clinical assessment. Cytokine levels between ‘study’ and ‘control’ arms (30 age & gender matched HIV-negative healthy volunteers) were compared. Independent unpaired t-test was done using Graph Pad Prism 6.0 to analyze differences statistically.

Results: Baseline cytokine levels were significantly high (p ≤ 0.05) in ARV naive HIV-positive subjects compared to healthy controls. Cytokine levels among treatment naive patients also correlated with severity of immunosuppression.

Conclusion: Biomarkers of inflammation (IL-6, TNF-α) and CRP were found to be high in ARV naïve HIV-positive subjects, enrolled at an Eastern Indian tertiary hospital. Extensive studies on baseline inflammatory profile of patients may be predictive of disease progression, treatment response and mortality.

Keywords: CD4 cell count, C-reactive protein (CRP), inflammatory markers, interleukine-6 (IL-6), plasma viral load (PVL), tumor necrosis factor-α (TNF-α).

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