摘要
背景:植物乳蓟和水飞蓟素传统上被用作治疗各种疾病的天然补救剂已有2000多年的历史,包括神经系统疾病如阿尔茨海默氏症,帕金森病和脑缺血症。 目的:在本文中,我们回顾了水飞蓟素对各种神经功能障碍的神经保护作用。 结果:水飞蓟素赋予的神经保护作用包括调节各种抗氧化机制,以及涉及细胞信号传导途径的几种激酶,抑制神经变性期间产生的炎症反应,神经营养因子,神经递质调节和凋亡抑制。可用性的便利性,比较低的成本和安全性特征为使用该化合物作为具有巨大临床益处的有效药物提供了额外的优点。然而,越来越需要改善水飞蓟素及相关产品的生物利用度,并且需要更一致和可靠的人类试验来准确地验证该天然化合物的神经保护功效。 结论:本综述中提到的研究结果令人期待,提供了对水飞蓟素在神经变性和神经退行性疾病与疾病进展病理学相关的各种神经变性疾病中的临床相关性的深入了解。
关键词: 阿尔茨海默病,神经退行性疾病,帕金森病,水飞蓟素,神经保护作用,氧化应激。
Current Drug Targets
Title:A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin
Volume: 18 Issue: 13
关键词: 阿尔茨海默病,神经退行性疾病,帕金森病,水飞蓟素,神经保护作用,氧化应激。
摘要: Background: The plant milk thistle and silymarin has been traditionally used as a natural remedy for the treatment of various ailments including neurological disorders such as Alzheimer’s and Parkinson's disease and cerebral ischemia for over 2000 years.
Objective: In this article we review the neuroprotective effects of silymarin against various neurological dysfunctions. Results: The neuroprotective effects conferred by silymarin include modulation of various antioxidant mechanisms, and several kinases involved in cell signaling pathways, inhibition of the inflammatory response generated during neurodegeneration, neurotropic effects, regulation of neurotransmitters and inhibition of apoptosis. The ease of availability, comparative low cost and safety profile provide additional advantages for the use of this compound as a potent drug with immense clinical benefit. However, there is a growing need for improvements in the bioavailability of silymarin and related products, and more consistent and reliable human trials are required to accurately validate the neuroprotective efficacy of this natural compound. Conclusion: The promising outcomes of the studies mentioned in this review provide renewed insight into the clinical relevance of silymarin in a variety of neurodegenerative disorders where neuroinflammation and oxidative stress are pathologically relevant to disease progression.Export Options
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Cite this article as:
A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161227125121
DOI https://dx.doi.org/10.2174/1389450117666161227125121 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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