摘要
SUMO化修饰是一种能够把小反诉样肽SUMO结合到基板上的共价蛋白后翻译修饰。SUMO化修饰与许多生物过程密切相关,包括细胞增殖、分化、衰老、凋亡等。因此,发现SUMO化修饰的失调在肿瘤的发生及不同种类的肿瘤依赖于功能性SUMO化通路不足为奇。SUMO化修饰作为肿瘤中一个治疗性靶点具有研发潜力。本文综述了与基因组稳定性和DNA损伤应答的SUMO化修饰现有的知识进行了综述,我们将进一步讨论SUMO化修饰在肿瘤干细胞中作为合成致死的搭档和关键的信号通路的治疗潜力。
关键词: SUMO化修饰,基因组稳定性,DNA损伤应答,合成致死,肿瘤干细胞
Current Molecular Medicine
Title:Sumoylation Pathway as Potential Therapeutic Targets in Cancer
Volume: 16 Issue: 10
关键词: SUMO化修饰,基因组稳定性,DNA损伤应答,合成致死,肿瘤干细胞
摘要: Sumoylation is a covalent protein posttranslational modification that conjugates the small ubiquitin-like peptide SUMO to substrate. Sumoylation is critically implicated in multiple biological processes, including cell proliferation, differentiation, senescence and apoptosis, etc. Therefore, it is not surprising that dysregulation of sumoylation has been implicated in tumorigenesis and different types of cancer were found to be addicted to functional sumoylation pathway. The potential role for sumoylation as a therapeutic target in caner is emerging. In this review, we summarize current knowledge regarding the involvement of sumoylation in genome stability and DNA damage response. We will further discuss the therapeutic potential of sumoylation as synthetic lethal partner and as a key signaling pathway in cancer stem cells.
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Sumoylation Pathway as Potential Therapeutic Targets in Cancer, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223105201
DOI https://dx.doi.org/10.2174/1566524016666161223105201 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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