Abstract
Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.
Keywords: Sumoylation, p53, RB, senescence, aging.
Current Molecular Medicine
Title:Sumoylation in Cellular Senescence and Aging
Volume: 16 Issue: 10
Author(s): L. Gong, Q. Sun and D. W.-C. Li
Affiliation:
Keywords: Sumoylation, p53, RB, senescence, aging.
Abstract: Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.
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Cite this article as:
Gong L., Sun Q. and Li W.-C. D., Sumoylation in Cellular Senescence and Aging, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223104915
DOI https://dx.doi.org/10.2174/1566524016666161223104915 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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