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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Tip60: Main Functions and Its Inhibitors

Author(s): Xiaoli Zhang, Jiyong Wu and Yepeng Luan*

Volume 17, Issue 8, 2017

Page: [675 - 682] Pages: 8

DOI: 10.2174/1389557516666160923125031

Price: $65


Background: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.

Results: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers.

Conclusion: Here, main functions and its known inhibitors were summarized.

Keywords: Cancer, ε-amino, HATs, HDACs, histone acetyltransferase, inhibitor, Tip60.

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