Title:Regulation of Platelet Function by Acetylation/Deacetylation Mechanisms
Volume: 23
Issue: 35
Author(s): Ana Latorre and Antonio Moscardó
Affiliation:
Keywords:
Acetylation, platelets, cardiovascular disease, aspirin, cancer, sirtuins.
Abstract: Reversible acetylation of histones is a well-known mechanism of
epigenetic regulation of gene expression. More recently, studies have demonstrated
that acetylation/deacetylation in several proteins regulate multiple
aspects of cellular activity, especially those associated with energetic metabolism.
Platelets are key participants in haemostasis and cardiovascular
diseases. Although metabolic changes such as diabetes or lipidemia are well
recognized risk factors for cardiovascular diseases, there is very little information
about the relationship between metabolism and platelet reactivity.
Recent studies have reported that different aspects of platelet function such
as adhesion, aggregation, or granule release could also be regulated by acetylation
of proteins. These cycles of acetylation/deacetylation are regulated by the contrasting
action of acetyltransferases and deacetylases, which have been described by the presence of
p300 and HDAC6, and sirtuins, respectively, in platelets. Remarkably, deacetylases, especially
sirtuins, have been the subjects of intensive pharmaceutical research due to their implication
in several physiological and pathological processes in organisms. The discovery of
acetylation mechanisms in platelets opens new possibilities for the treatment and prevention
of cardiovascular diseases through the regulation of acetylases/deacetylases in platelets.
Therefore, the aim of this review is to present some recent reports concerning the role of acetylation
of proteins in the control of platelet function, and the new possibilities of regulation
of platelet function that this represent.
