睾丸损伤和癌症后生殖功能恢复中的内源性因子

Title:Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer

Volume: 16 Issue: 7

Author(s): A. M.S. Silva, S. Correia, S. Socorro, C. J. Maia

Affiliation:

关键词: 化疗，放疗，男性不育，睾丸癌，保留生育功能

摘要: The testes are one of the most delicate organs in the male body and highly susceptible to the exogenous influences capable of inducing cell damage. Cancer therapies are well known to negatively affect the male reproductive tract with a severe impairment of spermatogenesis and infertility. The present work aimed to systematically review the available information about the different endogenous factors (hormonal and nonhormonal) that may have protective or advantageous properties on the recovery of male reproductive function after gonadal injury. Furthermore, the perspective that these endogenous molecules could act as cryoprotectants to improve the quality of cryopreserved semen samples was also discussed. The knowledge reviewed herein allowed to identify promising factors able to mitigate the male fertility problems arising either from oncological treatments or other gonadal damage, and opened new possibilities to ameliorate the recovery of spermatogenesis or to preserve fertility.

Cite this article as:

A. M.S. Silva, S. Correia, S. Socorro, C. J. Maia , Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer, Current Molecular Medicine 2016; 16 (7) . https://dx.doi.org/10.2174/1566524016666160802150400