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摘要
睾丸是男性身体的最易损的器官之一并且对能诱发细胞损害的外源性影响高度敏感。癌症治疗,有着精子发生的严重损害和不育,被公认对男性生殖道有消极影响。现在的工作目标是系统地评价不同的关于在性腺受损后男性生殖功能恢复中可能有保护的或有益特性的内源性因素(激素和非激素的)的可得到的信息。此外,这些内源性分子可当做保护剂来提高冷冻保存的精子样品的质量的观点也被讨论了。此处回顾的知识能鉴别能够减轻肿瘤治疗或其他性腺损伤引起的男性生育问题有希望的因子,并为改善精子发生恢复或维持生育能力开启了新的可能。
关键词: 化疗,放疗,男性不育,睾丸癌,保留生育功能
Current Molecular Medicine
Title:Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer
Volume: 16 Issue: 7
Author(s): A. M.S. Silva, S. Correia, S. Socorro, C. J. Maia
Affiliation:
关键词: 化疗,放疗,男性不育,睾丸癌,保留生育功能
摘要: The testes are one of the most delicate organs in the male body and highly susceptible to the exogenous influences capable of inducing cell damage. Cancer therapies are well known to negatively affect the male reproductive tract with a severe impairment of spermatogenesis and infertility. The present work aimed to systematically review the available information about the different endogenous factors (hormonal and nonhormonal) that may have protective or advantageous properties on the recovery of male reproductive function after gonadal injury. Furthermore, the perspective that these endogenous molecules could act as cryoprotectants to improve the quality of cryopreserved semen samples was also discussed. The knowledge reviewed herein allowed to identify promising factors able to mitigate the male fertility problems arising either from oncological treatments or other gonadal damage, and opened new possibilities to ameliorate the recovery of spermatogenesis or to preserve fertility.
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Cite this article as:
A. M.S. Silva, S. Correia, S. Socorro, C. J. Maia , Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer, Current Molecular Medicine 2016; 16 (7) . https://dx.doi.org/10.2174/1566524016666160802150400
DOI https://dx.doi.org/10.2174/1566524016666160802150400 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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