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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

1,3,4-Thiadiazole Based Anticancer Agents

Author(s): Alireza Aliabadi

Volume 16, Issue 10, 2016

Page: [1301 - 1314] Pages: 14

DOI: 10.2174/1871520616666160628100936

Price: $65


In recent years, researchers like medicinal chemists in the field of medicinal chemistry have widely utilized the 1,3,4-thiadiazole nucleus to investigate its biological and pharmacological effects. This heterocyclic structure has demonstrated various bioactivities such as antifungal, antimicrobial, antiviral, antileishmanial, anti-inflammatory, antihypertensive, antiepileptic, and anticancer effects among others. Anticancer activity is one of its promising effect as five membered heterocyclic rings have widely been investigated by researchers in the recent years. Herein, we reviewed the chemical structures bearing 1,3,4-thiadiazole template exerting anticancer activity.

Keywords: 1, 3, 4-Thiadiazole, anticancer, cytotoxicity, cell lines.

Graphical Abstract

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