Title:Prospects of Nanocarriers for Oral Delivery of Bioactives Using Targeting Strategies
Volume: 17
Issue: 8
Author(s): Neha N. Parayath, Hayley Nehoff, Sebastien Taurin and Khaled Greish
Affiliation:
Keywords:
Caco-2, Intestinal epithelium models, M cells, nanocarriers, oral delivery, oral insulin, oral vaccine, targeted delivery,
transcytosis.
Abstract: The oral route is the preferred mode of administration, however the poor intestinal absorption
of many bioactive compounds limit their efficacy. Several strategies have been developed to overcome
the low oral bioavailability of bioactive compounds. Nanocarriers present a unique opportunity
to overcome this limitation due to their diverse bioactive carriage potential, surface functionality and
design flexibility. Despite these favorable characteristics, the oral delivery of nanocarriers faces several
challenges which are discussed in this review. The review addresses the different mechanisms of
transport across the intestinal epithelium. In addition, we will comment on the various methods and models for evaluating
the intestinal permeability, with a critical discussion of the uniformity of these models in investigating the oral bioavailability
of nanocarrier systems. Finally, we will discuss some of the recently developed nanocarriers for oral delivery of
bioactives that show promising results.
