批准抗癌药物的多向药理学

Title:Polypharmacology of Approved Anticancer Drugs

Volume: 18 Issue: 5

关键词: 多向药理学，酪氨酸激酶抑制剂，组蛋白去乙酰化酶抑制剂，DNA拓扑异构酶抑制剂、他莫昔芬、药物靶点，多靶点药物的合理设计。

摘要: The major drug discovery efforts in oncology have been concentrated on the development of selective molecules that are supposed to act specifically on one anticancer mechanism by modulating a single or several closely related drug targets. However, a bird's eye view on data from multiple available bioassays implies that most approved anticancer agents do, in fact, target many more proteins with different functions. Here we will review and systematize currently available information on the targets of several anticancer drugs along with revision of their potential mechanisms of action. Polypharmacology of the current antineoplastic agents suggests that drug clinical efficacy in oncology can be achieved only via modulation of multiple cellular mechanisms.

Cite this article as:

Polypharmacology of Approved Anticancer Drugs, Current Drug Targets 2017; 18 (5) . https://dx.doi.org/10.2174/1389450117666160301095233