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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Freezing of Gait in Parkinsonism and its Potential Drug Treatment

Author(s): Li-Li Zhang, S. Duff Canning and Xiao-Ping Wang

Volume 14, Issue 4, 2016

Page: [302 - 306] Pages: 5

DOI: 10.2174/1570159X14666151201190040

open access plus


Freezing of gait (FOG) is a heterogeneous symptom. Studies of treatment for FOG are scarce. Levodopa and monoamine oxidase inhibitors (rasagiline and selegiline) have shown effective improvement for FOG. Other drugs, such as L-threo-3, 4-dihydroxyphenylserine, amantadine, and botulinum toxin have exhibited some beneficial effects. The present review summarizes the potential drug treatment for FOG in Parkinsonism.

Keywords: Drug treatment, freezing of gait, Levodopa, Parkinson’s disease, Parkinsonism.

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