Title:Quinoxalines Potential to Target Pathologies
Volume: 22
Issue: 26
Author(s): Maria Tristan-Manzano, Antonio Guirado, Maria Martinez-Esparza, Jesus Galvez, Pilar Garcia-Penarrubia and Antonio J. Ruiz-Alcaraz
Affiliation:
Keywords:
Biomedical activity, Intracellular signaling, Molecular targets, Receptors, Quinoxaline derivatives,
Therapeutic applications.
Abstract: The study of quinoxalines has increased immeasurably during the last two decades,
due firstly to their relatively simple chemical synthesis, which has generated a vast variety
of compounds with diverse structural modifications, and secondly, to the wide therapeutic potential and
biological activities exhibited by this family of compounds. Quinoxalines constitute a rising biomedical class
of low-molecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory,
antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents, as well as being of interest for the potential
treatment of glaucoma, insomnia, cardiovascular and neurological diseases, among others. However, a
deeper knowledge of the molecular targets of quinoxalines that fulfil a key role in certain pathologies is required
for the development of new and more specific drugs through a rational design strategy to avoid undesirable
side effects. In the present review, we summarize the most important molecular targets of the quinoxaline
derivatives discovered to date, thus providing a first reference index for researchers to identify the potential
targets of their quinoxalines derived collections, which could facilitate the development of new quinoxaline-
based therapies.
