Title:Targeting the Gut Microbiota for the Treatment of Non-Alcoholic Fatty Liver Disease
Volume: 16
Issue: 12
Author(s): Marialena Mouzaki and Robert Bandsma
Affiliation:
Keywords:
Bile acids, dysbiosis, fatty liver, microbiota, NAFLD, NASH.
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a challenge not only due to its rising prevalence
but also, and perhaps more importantly, due to the lack of sustainable treatment options. Intestinal
microbiota are thought to participate in the development and progression of NAFLD and their manipulation
is, hence, being investigated as a treatment aim. This review summarizes the involvement of
intestinal microbiota in the pathogenesis on NAFLD. In addition, we synthesize the results of the most
recent animal and human studies aimed at treating dysbiosis seen in patients with NAFLD. Lastly, we
review the evidence regarding the efficacy of manipulating short chain fatty acid and bile acid signaling
in the treatment of NAFLD.
