Title:The Crosstalk Between miRNA and Mammalian Circadian Clock
Volume: 22
Issue: 13
Author(s): Xia Wang, Guihua Tian, Zhongfeng Li and Lei Zheng
Affiliation:
Keywords:
Circadian clock, circadian dynamics, circadian output, miRNA, post-transcriptional regulation.
Abstract: Circadian clocks are present in most organisms to coordinate daily rhythms
in physiology and behavior. The general molecular mechanisms are based on interlocked
transcription-translation feedback loops driving rhythms in gene expression of a
series of core clock genes. Multiple levels of regulations including transcriptional, posttranscriptional
and post-translational mechanisms make circadian clock regulation more complex than once thought. Particularly,
accumulating evidences have shown that miRNAs are significant players in regulating various aspects of circadian
clock function. In this review, we will summarize the recent findings in the interplay of miRNAs and mammalian
circadian clock and discuss future perspectives for research on the role of miRNAs played in circadian timing in health
and disease.
