Title:Curcumin as an Adjuvant to Breast Cancer Treatment
Volume: 15
Issue: 5
Author(s): Parveen Kumar, Almesh Kadakol, Prashanth Krishna Shasthrula, Nitin Arunrao Mundhe, Vinayak Sudhir Jamdade, Chandana C. Barua and Anil Bhanudas Gaikwad
Affiliation:
Keywords:
Adjuvant, breast cancer, chemotherapy, curcumin, resistance.
Abstract: Cancer is the second largest leading cause of death worldwide and breast cancer is the most prevailing
cause of mortality among all cases of malignant neoplastic disease in adult females. The incidence rate of breast
malignant neoplastic disease is predominantly higher in Western women, when compared to women in Asian
nations. The definitive reason for this conflict is even unknown, but dietary factors have been conceived to account for approximately
30% of cancers in Western nations. It has been hypothesized that ethnicity, including use of a variety of spices in the food would be a
major reason. Among all spices, turmeric (Curcuma longa) has been proven for its better anticancer potential. In this review different
molecular mechanisms including cell cycle arrest; G0/G1 and/or G2/M phase cell cycle arrest by up-regulating Cdk inhibitor,
p21/WAF/CIPI and p53, inhibition of transcriptional factors; NFκB, AP-1, TNFα, IL, STAT-3, and PPAR-γ, downstream gene
regulation; c-myc, Bcl-2, COX-2, NOS, Cyclin D1, TNFα, interleukins and MMP-9, growth factors; bFGF, EGF, GCSF, IL-8, PDGF,
TGFα, TNF, VEGF and cell adhesion molecules; fibronectin, vitronectin, and collagen which are involved in angiogenesis and
metastasis, alsothe effectiveness of curcumin, when given in combination with chemotherapeutics like cyclophosphamide, doxorubicin,
mitomycin etc. in treating breast cancer have been reviewed.
