摘要
乳腺癌是女性最常见的恶性肿瘤,在每年新确诊的癌症中占近30%。到目前为止,各种治疗干预措施,包括手术、化疗、激素治疗和放疗都是有效的,且能使总死亡率大幅下降。然而,治疗性抗拒、复发和转移期治疗不足是需要解决的主要挑战。越来越多的证据表明在患乳腺癌的不同人口中,肿瘤干细胞CSCs的存在能够自我更新和分化,被认为是抗药性和复发的原因。因此,可以同时针对分化的癌细胞和肿瘤干细胞的化合物可能会提供更好的治疗方案。由于膳食剂和健康产品的安全性,研究者将它们引入临床试验来代替化疗药物。本综述着眼于植物化学物质,主要是黄酮类化合物,在乳腺癌治疗临床前阶段的应用。因为植物化学物质在乳腺癌和肿瘤干细胞中有多项优势,所以基于最有效天然分子,并通过合理的药物设计可合成新的系列类似化合物用于乳腺癌治疗。
关键词: 生物利用度,乳腺癌,肿瘤干细胞,大麻素类,黄酮类,植物化学物质,酪氨酸激酶
Current Cancer Drug Targets
Title:Phytochemicals for Breast Cancer Therapy: Current Status and Future Implications
Volume: 15 Issue: 2
Author(s): Jawed A. Siddiqui, Aru Singh, Megha Chagtoo, Nidhi Singh, Madan M. Godbole and Bandana Chakravarti
Affiliation:
关键词: 生物利用度,乳腺癌,肿瘤干细胞,大麻素类,黄酮类,植物化学物质,酪氨酸激酶
摘要: Breast cancer is one of the most common malignancies among women, representing nearly 30% of newly diagnosed cancers every year. Till date, various therapeutic interventions, including surgery, chemotherapy, hormonal therapy, and radiotherapy are available and are known to cause a significant decline in the overall mortality rate. However, therapeutic resistance, recurrence and lack of treatment in metastasis are the major challenges that need to be addressed. Increasing evidence suggests the presence of cancer stem cells (CSCs) in heterogeneous population of breast tumors capable of selfrenewal and differentiation and is considered to be responsible for drug resistance and recurrence. Therefore, compound that can target both differentiated cancer cells, as well as CSCs, may provide a better treatment strategy. Due to safe nature of dietary agents and health products, investigators are introducing them into clinical trials in place of chemotherapeutic agents.This current review focuses on phytochemicals, mainly flavonoids that are in use for breast cancer therapy in preclinical phase. As phytochemicals have several advantages in breast cancer and cancer stem cells, new synthetic series for breast cancer therapy from analogues of most potent natural molecule can be developed via rational drug design approach.
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Cite this article as:
Jawed A. Siddiqui, Aru Singh, Megha Chagtoo, Nidhi Singh, Madan M. Godbole and Bandana Chakravarti , Phytochemicals for Breast Cancer Therapy: Current Status and Future Implications, Current Cancer Drug Targets 2015; 15 (2) . https://dx.doi.org/10.2174/1568009615666141229152256
DOI https://dx.doi.org/10.2174/1568009615666141229152256 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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Cancer remains one of the most challenging diseases, with its complexity and adaptability necessitating continuous research efforts into more effective and targeted therapeutic approaches. Recent years have witnessed significant progress in understanding the molecular and genetic basis of cancer, leading to the identification of novel drug targets. These include, but ...read more
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Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process of exploring and investigating the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Unraveling the Tumor Microenvironment and Potential Therapeutic Targets: Insights from Single-Cell Sequencing and Spatial Transcriptomics
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