Title:Targeting Cancer Stem Cells as a Therapeutic Approach in Liver Cancer
Volume: 15
Issue: 2
Author(s): Gang Zhou, George Wilson, Jacob George and Liang Qiao
Affiliation:
关键词:
药物抗性，变异，肝癌，癌症干细胞， micro-RNA，自我更新，信号通路
摘要: Cancer stem cells (CSCs) are a subset of cells within tumours that have the ability to selfrenew,
differentiate and resist both chemotherapy and radiotherapy. Evidence has emerged in recent
years to support liver cancer stem cells (LCSCs) as the key tumour initiating cells and major drivers of
tumour progression in hepatocellular carcinoma (HCC). Currently the major approaches to targeting
LCSCs are ablating the expression of LCSC markers, disruption of key LCSCs signaling pathways,
micro-RNA or siRNA targeting, inducing differentiation of LCSCs and the disruption of chemoresistance
of LCSCs. However, complex crosstalk amongst gene regulatory pathways in LCSCs provides a
major barrier in implementing these approaches in a clinical setting. Given these findings a deeper understanding of the
pathways that mediate LCSC tumourigenesis is imperative for developing new therapeutic strategies for HCC and to improve
clinical outcomes.
