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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181


Commentary (Changes of Synaptic Plasticity in Multiple Sclerosis)

Author(s): Ti-Fei Yuan, Chunlei Shan and Oscar Arias-Carrion

Volume 14, Issue 2, 2015

Page: [152 - 154] Pages: 3

DOI: 10.2174/1871527313666141114203620


Patients with multiple sclerosis (MS) often suffer from cognitive dysfunction; the underlying mechanisms have not been fully elucidated. Recent studies suggest that MS leads to heightened synaptic transmission and plasticity in different brain areas, and therefore may contribute to the observed behavioral abnormalities. Recent findings demonstrate synaptic plasticity changes in MS, including evidence from animal models of experimental autoimmune encephalomyelitis and human MS patients.

Keywords: Experimental autoimmune encephalomyelitis, inflammation, multiple sclerosis, N-methyl-D-aspartic acid, synaptic plasticity, trophic factor.

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