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Current Green Chemistry

Editor-in-Chief

ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

Flow and Microwave Assisted Synthesis of Medicinally Relevant Indoles

Author(s): Nadeesha Ranasinghe and Graham B. Jones

Volume 2, Issue 1, 2015

Page: [66 - 76] Pages: 11

DOI: 10.2174/2213346101666140613224003

Price: $65

Abstract

The indole ring is one of the most abundant heterocyclic scaffolds found in nature. It is built into the essential amino acid tryptophan in which the arene component of the indole facilitates π-π interactions, and the N-H group serving as a hydrogen bond donor to proximal proteinogenic species. Accordingly, the indole sub-structure forms an essential component of the framework of higher order protein structures. Although myriad synthetic routes exist to access the indole nucleus including the venerable Fisher indole synthesis and other named reactions, new methods and modifications to the existing methods remain a key area of research. Drivers include improving regioselectivity for functionalizing the core, and the need for greener approaches. Microwave and flow mediated methods have been an area of significant interest to address these issues, and this mini review will survey recent advances in the field.

Keywords: Flow, indoles, medicinal, microwave, tryptophans.

Graphical Abstract

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