Abstract
The role of melatonin in glucose homeostasis is an active area of investigation. There is a growing body of evidence suggesting a link between disturbances in melatonin production and impaired insulin, glucose, lipid metabolism, and antioxidant capacity. Furthermore, melatonin has been found to influence insulin secretion both in vivo and in vitro, and night-time melatonin levels are related to night-time insulin concentrations in patients with diabetes. In several recent studies, a single nucleotide polymorphism of the human melatonin receptor 1B has been described as being causally linked to an increased risk of developing type 2 diabetes. Taken together, these data suggest that endogenous as well as exogenous melatonin may play a role in diabetes and associated metabolic disturbances not only by regulating insulin secretion but also by providing protection against reactive oxygen species, considering pancreatic β-cells are particularly susceptible to oxidative stress because they possess only low-antioxidative capacity.
Keywords: Diabetes, glucagon, glucose, insulin, melatonin, melatonin receptors, metabolic syndrome, oxidative stress.
Current Pharmaceutical Design
Title:Melatonin and Glucose Metabolism: Clinical Relevance
Volume: 20 Issue: 30
Author(s): Lardone P.J., Alvarez-Sanchez Sanchez N., Guerrero J.M. and Carrillo-Vico A.
Affiliation:
Keywords: Diabetes, glucagon, glucose, insulin, melatonin, melatonin receptors, metabolic syndrome, oxidative stress.
Abstract: The role of melatonin in glucose homeostasis is an active area of investigation. There is a growing body of evidence suggesting a link between disturbances in melatonin production and impaired insulin, glucose, lipid metabolism, and antioxidant capacity. Furthermore, melatonin has been found to influence insulin secretion both in vivo and in vitro, and night-time melatonin levels are related to night-time insulin concentrations in patients with diabetes. In several recent studies, a single nucleotide polymorphism of the human melatonin receptor 1B has been described as being causally linked to an increased risk of developing type 2 diabetes. Taken together, these data suggest that endogenous as well as exogenous melatonin may play a role in diabetes and associated metabolic disturbances not only by regulating insulin secretion but also by providing protection against reactive oxygen species, considering pancreatic β-cells are particularly susceptible to oxidative stress because they possess only low-antioxidative capacity.
Export Options
About this article
Cite this article as:
P.J. Lardone, Sanchez N. Alvarez-Sanchez, J.M. Guerrero and A. Carrillo-Vico, Melatonin and Glucose Metabolism: Clinical Relevance, Current Pharmaceutical Design 2014; 20 (30) . https://dx.doi.org/10.2174/1381612819666131119101032
DOI https://dx.doi.org/10.2174/1381612819666131119101032 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Staging of Breast Cancer with 18F-FDG PET and PET/CT
Current Medical Imaging Applications of Extremophilic Archaeal Lipids in the Field of Nanocarriers for Oral/Topical Drug Delivery
Current Biotechnology Defective and Excessive Immunities in Pediatric Diseases
Current Pharmaceutical Design Collagen Cross-link Breakers:A Beginning of a New Era in the Treatment of Cardiovascular Changes Associated with Aging,Diabetes,and Hypertension
Current Drug Targets - Cardiovascular & Hematological Disorders Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects
Current Drug Metabolism Curcumin-based Antioxidant and Glycohydrolase Inhibitor Compounds: Synthesis and <i>In Vitro</i> Appraisal of the Dual Activity Against Diabetes
Medicinal Chemistry Preface [Hot Topic: Nitric Oxide (Guest Editor: Bahar Tunctan)]
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Neuroprotective Properties of Erythropoietin in Cerebral Ischemia
Central Nervous System Agents in Medicinal Chemistry Novel Concepts of Statin Therapy for Cardiovascular Risk Reduction in Hypertension
Current Pharmaceutical Design Paliperidone Use in the Elderly
Current Drug Safety Production of Pancreatic Beta-Cells from Stem Cells
Current Diabetes Reviews Wharton’s Jelly or Bone Marrow Mesenchymal Stromal Cells Improve Cardiac Function Following Myocardial Infarction for More Than 32 Weeks in a Rat Model: A Preliminary Report
Current Stem Cell Research & Therapy Impact of IL-17 on Cells of the Monocyte Lineage in Health and Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets From Biomarkers to Cytokine-like Hormones: Uncovering New Directives for Cognitive Loss and Alzheimer’s Disease
Current Neurovascular Research An Overview of the Modulatory Effects of Oleic Acid in Health and Disease
Mini-Reviews in Medicinal Chemistry Neurovascular Signals Suggest a Propagation Mechanism for Endogenous Stem Cell Activation Along Blood Vessels
CNS & Neurological Disorders - Drug Targets Small Molecule Inhibitors of Human Adipocyte Fatty Acid Binding Protein (FABP4)
Medicinal Chemistry Prevalence and Clinical Profile of Undiagnosed Diabetes Mellitus: Data from a Tertiary Hospital
Endocrine, Metabolic & Immune Disorders - Drug Targets Insights into the Platelet Releasate
Current Pharmaceutical Design The Pathophysiology of Uric Acid in Relation to Cardiovascular Disease
Current Cardiology Reviews