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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Melatonin and Glucose Metabolism: Clinical Relevance

Author(s): Lardone P.J., Alvarez-Sanchez Sanchez N., Guerrero J.M. and Carrillo-Vico A.

Volume 20, Issue 30, 2014

Page: [4841 - 4853] Pages: 13

DOI: 10.2174/1381612819666131119101032

Price: $65

Abstract

The role of melatonin in glucose homeostasis is an active area of investigation. There is a growing body of evidence suggesting a link between disturbances in melatonin production and impaired insulin, glucose, lipid metabolism, and antioxidant capacity. Furthermore, melatonin has been found to influence insulin secretion both in vivo and in vitro, and night-time melatonin levels are related to night-time insulin concentrations in patients with diabetes. In several recent studies, a single nucleotide polymorphism of the human melatonin receptor 1B has been described as being causally linked to an increased risk of developing type 2 diabetes. Taken together, these data suggest that endogenous as well as exogenous melatonin may play a role in diabetes and associated metabolic disturbances not only by regulating insulin secretion but also by providing protection against reactive oxygen species, considering pancreatic β-cells are particularly susceptible to oxidative stress because they possess only low-antioxidative capacity.

Keywords: Diabetes, glucagon, glucose, insulin, melatonin, melatonin receptors, metabolic syndrome, oxidative stress.


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