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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Emerging Role of the Ubiquitin-proteasome System as Drug Targets

Author(s): Gozde Kar, Ozlem Keskin, Franca Fraternali and Attila Gursoy

Volume 19, Issue 18, 2013

Page: [3175 - 3189] Pages: 15

DOI: 10.2174/1381612811319180002

Price: $65


The ubiquitin-proteosome system (UPS) regulates a wide range of cellular processes including protein degradation, DNA repair, transcription regulation, and cell signaling. Alterations and mutations in UPS components give rise to various human diseases, most prominently cancer and neurodegenerative disorders. Here, we review recent advances in UPS-based drug discovery highlighting the emerging relationships between the UPS and disease and discuss potential future therapeutic interventions. In particular, we focus on recent structural approaches in UPS and explain how the knowledge of protein structural details can guide the design of specifically targeted inhibitors.

Keywords: Ubiquitin-proteosome system, disease, drug design.

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