Title:Autoimmune Hepatitis: Pathophysiology, Diagnosis and Pharmacological Therapy
Volume: 8
Issue: 4
Author(s): Vanessa Neves Brondani, Michel Mansur Machado and Luis Flavio Souza de Oliveira
Affiliation:
Keywords:
Autoimmune hepatitis, diagnosis, non-viral hepatitis, pathophysiology, treatment
Abstract: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease, rare and of unknown etiology, that affects
patients who lack tolerance to self antigens. Genetic and environmental factors are related to the disease etiology. The
pathology, mainly prevalent in females, is characterized by the presence of interface hepatitis with biochemical changes,
such as increased levels of transaminase, the presence of hypergammaglobulinemia and circulating autoantibodies.
Antibodies classify the types of the disease. Due to the heterogeneity of symptoms, the diagnostic criteria are not unique
since they are based on a combination of clinical, biochemical, immunological and histological features. AIH should be
diagnosed in its early stages due to possible cirrhosis evolution when untreated. Standard and most effective treatment
consists of corticosteroids in combination or not with azathioprine. AIH has a good prognosis with good resolution of
symptoms when properly treated, albeit with relapse at an early withdrawal.
