Title:Polyglandular Autoimmune Syndromes
Volume: 8
Issue: 4
Author(s): Khaled El Baba, Mira Zantout and Sami T. Azar
Affiliation:
Keywords:
Addison’s disease, AIRE gene mutation, candidiasis, chronic hypoparathyroidism, Hashimoto's thyroiditis,
hyperthyroidism, polyglandular autoimmune syndromes, type I diabetes mellitus
Abstract: Polyglandular Autoimmune Syndromes (PAS) form different clusters of autoimmune disorders characterized
by the coexistence of at least two glandular autoimmune mediated diseases [1]. They are generally classified into three
types: a very rare juvenile type 1(PAS I) and a relatively common adult type with (PAS II) or without adrenal failure
(PAS III) [2, 3]. PAS I, also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), is
associated with candidiasis, hypoparathyroidism, and adrenal failure. PAS II is associated with adrenal failure, thyroid
diseases and type 1 diabetes mellitus. In this review we will shed light on both types of PAS including their clinical
picture and ways of management.
