Abstract
Many approaches have been applied in biological and clinical studies aimed at simultaneously monitoring the expression of a large number of genes and at identifying the gene expression patterns associated with specific cell types. In the last decade, microarrays are emerged as an innovative tool to detect differentially expressed genes as disease-specific markers and to cluster the co-expressed genes regulating the molecular interactions. In fact, microarrays have been widely used for tumour diagnosis and classification, prediction of prognoses and treatment, pharmaceutical safety assessment, and understanding of molecular mechanisms, biochemical pathways, and gene networks. Besides the clinical relevance and the wide application of this technology, several problems remain to be addressed. This review illustrates the current and future directions of the microarray platform, and highlights the successes and strengths, as well as the shortcomings and limitations of this technology. An overview of microarray impact on the ocular and craniofacial diseases is provided.
Keywords: Craniofacial diseases, Gene expression, Microarray analysis, Ocular diseases
Current Pharmaceutical Analysis
Title: Microarrays as a Tool for Gene Expression Profiling: Application in Ocular and Craniofacial Research
Volume: 3 Issue: 3
Author(s): Maria Visalli, Mario Venza, Isabella Venza, Claudia Torino and Diana Teti
Affiliation:
Keywords: Craniofacial diseases, Gene expression, Microarray analysis, Ocular diseases
Abstract: Many approaches have been applied in biological and clinical studies aimed at simultaneously monitoring the expression of a large number of genes and at identifying the gene expression patterns associated with specific cell types. In the last decade, microarrays are emerged as an innovative tool to detect differentially expressed genes as disease-specific markers and to cluster the co-expressed genes regulating the molecular interactions. In fact, microarrays have been widely used for tumour diagnosis and classification, prediction of prognoses and treatment, pharmaceutical safety assessment, and understanding of molecular mechanisms, biochemical pathways, and gene networks. Besides the clinical relevance and the wide application of this technology, several problems remain to be addressed. This review illustrates the current and future directions of the microarray platform, and highlights the successes and strengths, as well as the shortcomings and limitations of this technology. An overview of microarray impact on the ocular and craniofacial diseases is provided.
Export Options
About this article
Cite this article as:
Maria Visalli , Mario Venza , Isabella Venza , Claudia Torino and Diana Teti , Microarrays as a Tool for Gene Expression Profiling: Application in Ocular and Craniofacial Research, Current Pharmaceutical Analysis 2007; 3 (3) . https://dx.doi.org/10.2174/157341207781369312
DOI https://dx.doi.org/10.2174/157341207781369312 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Trends in Cell-Based Electrochemical Biosensors
Current Medicinal Chemistry Daphnane-Type Diterpene Orthoesters and their Biological Activities
Mini-Reviews in Medicinal Chemistry Targeted Drugs and Nanomedicine: Present and Future
Current Pharmaceutical Design BCR/ABL1 Fusion Transcripts Generated from Alternative Splicing: Implications for Future Targeted Therapies in Ph+ Leukaemias
Current Molecular Medicine Research Progress on hCNT3 Structure/Function and Nucleoside Anticancer Drugs
Current Protein & Peptide Science MICA Molecules in Disease and Transplantation, a Double-Edged Sword?
Current Immunology Reviews (Discontinued) Update to: The Aryl Hydrocarbon Receptor in Anticancer Drug Discovery: Friend or Foe?
Medicinal Chemistry Reviews - Online (Discontinued) Cryopreservation of Ovarian Tissue: State of the Art in 2007
Current Women`s Health Reviews Doxorubicin: The Good, the Bad and the Ugly Effect
Current Medicinal Chemistry Current Status of Leukemia Cytotherapy - Exploitation with Immune Cells
Current Stem Cell Research & Therapy Advances in DNA-Ligands with Groove Binding, Intercalating and/or Alkylating Activity: Chemistry, DNA-Binding and Biology
Current Medicinal Chemistry Presenilin and γ -Secretase Activity: A Viable Therapeutic Target for Alzheimers Disease?
Current Signal Transduction Therapy Therapeutic Potential of Peptide Toxins that Target Ion Channels
Inflammation & Allergy - Drug Targets (Discontinued) Systemic and Biophase Bioavailability and Pharmacokinetics of Nanoparticulate Drug Delivery Systems
Current Drug Delivery <i>Anastatica hierochuntica </i>Extracts: Promising, Safe and Selective Anticancer Agents
The Natural Products Journal Recent Studies on Natural Products as Anticancer Agents
Current Topics in Medicinal Chemistry Making Sense of Molecular Signatures in The Immune System
Combinatorial Chemistry & High Throughput Screening Isothymusin, a Potential Inhibitor of Cancer Cell Proliferation: An In Silico and In Vitro Investigation
Current Topics in Medicinal Chemistry NK Cell Function in HIV-1 Infection
Current HIV Research Fighting Tumor Cell Survival: Advances in the Design and Evaluation of Pim Inhibitors
Current Medicinal Chemistry