Title:A Proprietary Topical Preparation Containing EGCG-Stearate and Glycerin with Inhibitory Effects on Herpes Simplex Virus: Case Study
Volume: 11
Issue: 5
Author(s): Man Zhao, Jinyan Jiang, Rongrong Zheng, Henna Pearl, Douglas Dickinson, Baiping Fu and Stephen Hsu
Affiliation:
Keywords:
Cold sore, green tea polyphenol, herpes labialis, herpes simplex virus, herpes stomatitis, EGCG-Stearate, proprietary topical preparation, EGCG-acyl ester, HSV-1, HSV-2.
Abstract: The effects of a proprietary topical formulation containing EGCG-stearate in 100% glycerin USP were studied
in two volunteer patients with recurrent herpes simplex (HSV) type 1. Application during early onset (prodromal stage) in
a patient with herpes labialis prevented lesion progression. In a second patient with herpetic stomatitis, application of the
formula during a later stage (inflammation stage) led to a remarkably shortened duration of symptoms. In contrast, a third
patient provided 100% glycerin USP only as placebo failed to demonstrate any therapeutic or preventive effect against
lesion occurrence or duration of lesion and healing time. These results suggest that this proprietary topical preparation
could be used effectively to prevent and treat HSV-induced symptoms, and warrants further clinical investigation.
