Abstract
In this paper we describe test methods useful to evaluate the performance of Ge/ Ga generators and to assess radionuclidic purity of the eluates. In our tests on the elution profile of the generator, we found that less than 8.0 ml are sufficient to recover > 98 % of the activity. Elution yield was conforming the manufacturer specifications, being initially > 85 % and still > 64 % after 7 months of use. 68Ge breakthrough in the eluates was limited; even if radionuclidic purity was > 99.99 % , further analyses, in addition to physical tests, is recommended in order to assess chemical impurities that could determine interferences in labelling procedures.
Keywords: Ga/, Ge generator, radionuclidic purity, quality assurance
Current Radiopharmaceuticals
Title: Acceptance Tests and Quality Control of Ge/ Ga Generators
Volume: 2 Issue: 3
Author(s): Gianfranco Cicoria, Mario Marengo, Davide Pancaldi, Donato Di Pierro, Anna Rizzello, Filippo Lodi, Stefano Fanti and Stefano Boschi
Affiliation:
Keywords: Ga/, Ge generator, radionuclidic purity, quality assurance
Abstract: In this paper we describe test methods useful to evaluate the performance of Ge/ Ga generators and to assess radionuclidic purity of the eluates. In our tests on the elution profile of the generator, we found that less than 8.0 ml are sufficient to recover > 98 % of the activity. Elution yield was conforming the manufacturer specifications, being initially > 85 % and still > 64 % after 7 months of use. 68Ge breakthrough in the eluates was limited; even if radionuclidic purity was > 99.99 % , further analyses, in addition to physical tests, is recommended in order to assess chemical impurities that could determine interferences in labelling procedures.
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Cite this article as:
Cicoria Gianfranco, Marengo Mario, Pancaldi Davide, Di Pierro Donato, Rizzello Anna, Lodi Filippo, Fanti Stefano and Boschi Stefano, Acceptance Tests and Quality Control of Ge/ Ga Generators, Current Radiopharmaceuticals 2009; 2 (3) . https://dx.doi.org/10.2174/1874471010902030165
DOI https://dx.doi.org/10.2174/1874471010902030165 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
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