Generic placeholder image

Recent Patents on Inflammation & Allergy Drug Discovery


ISSN (Print): 1872-213X
ISSN (Online): 2212-2710

Pharmacological Modulation of Th17

Author(s): Juan B. De Sanctis, Jenny V. Garmendia, Dolores Moreno, Nancy Larocca, Michael Mijares, Camilo Di Giulio, Margarita Salazar-Bookaman, Gabriella Wojewodka and Danuta Radzioch

Volume 3, Issue 2, 2009

Page: [149 - 156] Pages: 8

DOI: 10.2174/187221309788489814

Price: $65


Recently, a third subset of Th17 cells has been described. This T helper subset induces the release of chemokines and growth factors and causes neutrophil accumulation in several mammalian organs. Pharmacological intervention blocking Th17 generation as well as IL-17 signaling might prove useful in a variety of diseases including asthma, chronic obstructive pulmonary disease, Crohns disease, cystic fibrosis, multiple sclerosis, psoriatic disease and rheumatoid arthritis. Here, we describe the patents that address a potential pharmacological use of promoting or targeting IL-17.

Keywords: IL-17, IL-17 receptors, Th-17, Th-1, Th-2, autoimmune diseases, allergic diseases, retinoids, retinoid orphan receptors, inflammation

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy