Title: Pharmacological Modulation of Th17
Volume: 3
Issue: 2
Author(s): Juan B. De Sanctis, Jenny V. Garmendia, Dolores Moreno, Nancy Larocca, Michael Mijares, Camilo Di Giulio, Margarita Salazar-Bookaman, Gabriella Wojewodka and Danuta Radzioch
Affiliation:
Keywords:
IL-17, IL-17 receptors, Th-17, Th-1, Th-2, autoimmune diseases, allergic diseases, retinoids, retinoid orphan receptors, inflammation
Abstract: Recently, a third subset of Th17 cells has been described. This T helper subset induces the release of chemokines and growth factors and causes neutrophil accumulation in several mammalian organs. Pharmacological intervention blocking Th17 generation as well as IL-17 signaling might prove useful in a variety of diseases including asthma, chronic obstructive pulmonary disease, Crohns disease, cystic fibrosis, multiple sclerosis, psoriatic disease and rheumatoid arthritis. Here, we describe the patents that address a potential pharmacological use of promoting or targeting IL-17.
