Title: Dynamics of CD86 Expression on Allergic Inflammation - New Insights
Volume: 3
Issue: 2
Author(s): Celso Pereira, Beatriz Tavares, Graca Loureiro, Artur Paiva, Ana Henriques, Margarida Abrantes, Daniel Machado, Filomena Botelho and Manuel F. Baganha
Affiliation:
Keywords:
Allergic inflammation, CD86, CD80, costimulatory molecules
Abstract: CD86 is a well-known costimulatory molecule in its interaction with CD28 and/or CTLA present on T cells, and is essential for full activation of naive T-cell and subsequent differentiation. Usually the B7 molecules are expressed mainly on APCs and B cells and in specific conditions on other activated cells. These costimulatory molecules are involved in the development of allergic inflammation and airways hyperreactivity (AHR) in allergen-challenged mice. Activated T cells, CD4+CD25+, express CD86 in the first 60 minutes after the specific inhalatory exposure. These T cells can be relevant in IgE mediated allergic reaction possibly by an autocrine costimulation via CD28/CTLA activation pathway. The blockage of the expression of CD86 could be a potential therapeutical target to reduce the magnitude or the progression of the allergic reaction. The review article also discussed relevant patents.
