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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Recent Progress in Discovery and Development of Antimitotic Agents

Author(s): Alex Kiselyov, Konstantin V. Balakin, Sergey E. Tkachenko, Nikolay Savchuk and Alexandre V. Ivachtchenko

Volume 7, Issue 2, 2007

Page: [189 - 208] Pages: 20

DOI: 10.2174/187152007780058650

Price: $65


This review highlights structural diversity of antimitotic agents. In particular, we emphasized current antimitotic therapies based on modulation of microtubule dynamics. With several successful anticancer drugs on the market and numerous compounds in clinical developments, tubulin-binding agents remain among the most important categories of anticancer agents. Compounds targeting mitotic kinases and kinesins are also discussed.

Keywords: antimitotic agent, inhibitor of tubulin polymerization, microtubule-stabilizing agent, mitotic kinesin, mitotic kinase

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