Title: The New Immunosuppression: Intervention at the Dendritic Cell-T-Cell Interface
Volume: 5
Issue: 4
Author(s): A. M. Paterson, S. F. Yates, K. F. Nolan and H. Waldmann
Affiliation:
Keywords:
Dendritic cells, T cells, immunological synapse, antibodies, pharmacological agents, tolerance
Abstract: Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a tolerogenic context. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function.
