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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy

Author(s): Chiara Riganti, Elisabetta Aldieri, Sophie Doublier, Amalia Bosia and Dario Ghigo

Volume 8, Issue 6, 2008

Page: [609 - 618] Pages: 10

DOI: 10.2174/138955708784534436

Price: $65


Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.

Keywords: Rho GTPases, cancer, isoprenylation, statins, chemotherapy

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