Abstract
With the recent sequencing of its entire genome, the yeast Saccharomyces cerevisiae has gained considerable interest in the field of anticancer research. The genetic properties of the yeast allow easy selection of a variety of mutants, as their related phenotypes provide valuable information on anticancer drugs effects in vivo. Moreover, the yeast has been extensively studied as a model system to decipher basic cellular processes that are well conserved from yeast to human and implicated in cancer establishment and progression. We discuss the advantages of Saccharomyces cerevisiae for investigating the metabolism of pyrimidines, a major target for anticancer chemotherapy. We also emphasize the links between basic science in the pyrimidine metabolism and new anticancer antimetabolites as well as future prospects in this field.
Keywords: saccharomyces cerevisiae, cancer, chemotherapy, pyrimidine metabolism
Current Pharmacogenomics
Title: Saccharomyces Cerevisiae as a Genetic Model in Anticancer Therapy
Volume: 3 Issue: 1
Author(s): J. E. Kurtz, P. Dufour, J. P. Bergerat and F. Exinger
Affiliation:
Keywords: saccharomyces cerevisiae, cancer, chemotherapy, pyrimidine metabolism
Abstract: With the recent sequencing of its entire genome, the yeast Saccharomyces cerevisiae has gained considerable interest in the field of anticancer research. The genetic properties of the yeast allow easy selection of a variety of mutants, as their related phenotypes provide valuable information on anticancer drugs effects in vivo. Moreover, the yeast has been extensively studied as a model system to decipher basic cellular processes that are well conserved from yeast to human and implicated in cancer establishment and progression. We discuss the advantages of Saccharomyces cerevisiae for investigating the metabolism of pyrimidines, a major target for anticancer chemotherapy. We also emphasize the links between basic science in the pyrimidine metabolism and new anticancer antimetabolites as well as future prospects in this field.
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Cite this article as:
Kurtz E. J., Dufour P., Bergerat P. J. and Exinger F., Saccharomyces Cerevisiae as a Genetic Model in Anticancer Therapy, Current Pharmacogenomics 2005; 3 (1) . https://dx.doi.org/10.2174/1570160053175045
DOI https://dx.doi.org/10.2174/1570160053175045 |
Print ISSN 1570-1603 |
Publisher Name Bentham Science Publisher |
Online ISSN 1570-1603 |
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