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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

The Hedgehog Knows Many Tricks

Author(s): Glen J. Weiss, Alain C. Mita and Daniel D. Von Hoff

Volume 12, Issue 14, 2011

Page: [2091 - 2095] Pages: 5

DOI: 10.2174/138945011798829429

Price: $65


Contrary to the Classical Greek poet Archilochus phrase “The fox knows many things but the hedgehog knows one big thing”, the Hedgehog (HH) signaling pathway knows at least 3 ways to promote or support carcinogenesis. In this review, we provide a summary of the HH signaling pathway, and detail the clinical relevance and treatment of patients. Finally, future directions in exploiting this promising pathway will be addressed.

Keywords: Hedgehog pathway, cancer, treatment, mutation, autocrine, paracrine, signaling, clinical trial, carcinogenesis, PTCH1

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