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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Mini-Review Article

CircRNA Interference Pathway: A New Target for Intervention in Different Stages of Heart Failure

Author(s): Yuli Wang, Qiaoling Chen, Jiaqi Zhang, Yun Deng, Changyu Liu, Shuangcui Wang, Maojuan Guo* and Lili Song*

Volume 24, Issue 17, 2024

Published on: 24 May, 2024

Page: [1451 - 1463] Pages: 13

DOI: 10.2174/0115680266300535240514104107

Price: $65

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Abstract

Cardio-cerebrovascular disease has seen a rapid rise in recent years, with Heart Failure (HF) - a terminal stage of various cardiovascular diseases - also on the rise. HF has a complex pathogenesis involving multiple factors, such as inflammation, fibrosis, and oxidative stress. Due to its unique reverse shear mechanism, HF exhibits distinct expression patterns across different diseases. CircRNA has been linked to conditions like cancer, diabetes, and osteoarthritis. This article briefly introduces the mechanisms of circRNA biogenesis and its associated biological functions, focusing on CircSLC8A1-1, CircRNA_000203, and others at the early stage of HF, CircRNA PAN3, CircRNA (ACR), and others during the progression of HF, and CircHIPK3, CircNfix, and others at the end stage of HF. These circRNAs play a participatory role in the exact mechanism. As a research method, circRNA can be utilized to study the pathogenesis of heart failure and serve as a target for drug discovery and development. Therefore, circRNA's ability to mark the disease at different stages has significant guiding implications for HF monitoring, treatment, and prognosis.

Keywords: circRNA, Heart failure, Myocardial, Hypertrophy, Fibrosis, Apoptosis, Autophagy.

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