Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

A Comprehensive Guide to the Development, Evaluation, and Future Prospects of Self-nanoemulsifying Drug Delivery Systems for Poorly Water-soluble Drugs

Author(s): Abhishek Chauhan, Raj Kamal, Ritika Mishra, Devank Shekho and Ankit Awasthi*

Volume 30, Issue 16, 2024

Published on: 05 April, 2024

Page: [1211 - 1216] Pages: 6

DOI: 10.2174/0113816128296705240327065131

Price: $65

Abstract

Self-nano Emulsifying Drug Delivery Systems (SNEDDS) are novel formulations that can enhance the solubility and bioavailability of poorly water-soluble drugs. SNEDDS are composed of lipids, surfactants, co-solvents, and drugs and can spontaneously form nanoemulsions when mixed with water under mild agitation. SNEDDS can be formulated as liquid or solid dosage forms and can improve drug absorption by increasing the interfacial area, protecting the drug from degradation, and facilitating lymphatic transport. SNEDDS is characterized by various parameters such as particle size, zeta potential, droplet morphology, emulsification efficiency, drug solubility, and stability. SNEDDS offers several advantages over conventional dosage forms, such as dose reduction, faster onset of action, reduced variability, versatility, and ease of formulation. However, SNEDDS also face some limitations and challenges, such as drug precipitation, cost-effectiveness, compatibility with capsule shells, and lack of predictive in vitro models. SNEDDS has a promising future in the field of pharmaceuticals, especially for personalized medicine and targeted drug delivery.

Keywords: SNEDDS, nanoemulsion, bioavailability, solubility, self-emulsification, water-soluble drugs.

Next »
[1]
Neubert RHH. Potentials of new nanocarriers for dermal and transdermal drug delivery. Eur J Pharm Biopharm 2011; 77(1): 1-2.
[http://dx.doi.org/10.1016/j.ejpb.2010.11.003] [PMID: 21111043]
[2]
Tadros T, Izquierdo P, Esquena J, Solans C. Formation and stability of nano-emulsions. Adv Colloid Interface Sci 2004; 108-109: 303-18.
[http://dx.doi.org/10.1016/j.cis.2003.10.023] [PMID: 15072948]
[3]
Constantinides PP, Chaubal MV, Shorr R. Advances in lipid nanodispersions for parenteral drug delivery and targeting. Adv Drug Deliv Rev 2008; 60(6): 757-67.
[http://dx.doi.org/10.1016/j.addr.2007.10.013] [PMID: 18096269]
[4]
Date A, Nagarsenker M. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm 2007; 329(1-2): 166-72.
[http://dx.doi.org/10.1016/j.ijpharm.2006.08.038] [PMID: 17010543]
[5]
Alander J, Warnheim T. Model microemulsions containing vegetable oils part 1: Nonionic surfactant systems. J Am Oil Chem Soc 1989; 66(11): 1656-60.
[http://dx.doi.org/10.1007/BF02636197]
[6]
Grove M, Pedersen GP, Nielsen JL, Müllertz A. Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats-effect of medium and long chain triglycerides. J Pharm Sci 2005; 94(8): 1830-8.
[http://dx.doi.org/10.1002/jps.20403] [PMID: 15986460]
[7]
Dixit RP, Nagarsenker MS. Formulation and in vivo evaluation of self-nanoemulsifying granules for oral delivery of a combination of ezetimibe and simvastatin. Drug Dev Ind Pharm 2008; 34(12): 1285-96.
[http://dx.doi.org/10.1080/03639040802071570] [PMID: 18720144]
[8]
Cole ET, Cadé D, Benameur H. Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration. Adv Drug Deliv Rev 2008; 60(6): 747-56.
[http://dx.doi.org/10.1016/j.addr.2007.09.009] [PMID: 18096270]
[9]
Bowtle WJ. Materials, process, and manufacturing considerations for lipid-based hard-capsule formats. DRUGSPHARMAC SCI 2007; 170: 79.
[10]
Singh B, Singh R, Bandyopadhyay S, Kapil R, Garg B. Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol. Colloids Surf B Biointerfaces 2013; 101: 465-74.
[http://dx.doi.org/10.1016/j.colsurfb.2012.07.017] [PMID: 23010056]
[11]
Mu H, Holm R, Müllertz A. Lipid-based formulations for oral administration of poorly water-soluble drugs. Int J Pharm 2013; 453(1): 215-24.
[http://dx.doi.org/10.1016/j.ijpharm.2013.03.054] [PMID: 23578826]
[12]
Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm 2007; 66(2): 227-43.
[http://dx.doi.org/10.1016/j.ejpb.2006.10.014] [PMID: 17127045]
[13]
Shakeel F, Iqbal M, Ezzeldin E. Bioavailability enhancement and pharmacokinetic profile of an anticancer drug ibrutinib by self-nanoemulsifying drug delivery system. J Pharm Pharmacol 2016; 68(6): 772-80.
[http://dx.doi.org/10.1111/jphp.12550] [PMID: 27018771]
[14]
Singh B, Bandopadhyay S, Kapil R, Singh R, Katare OP. Self-emulsifying drug delivery systems (SEDDS): Formulation development, characterization, and applications. Crit Rev Ther Drug Carrier Syst 2009; 26(5)
[15]
Nielsen FS, Petersen KB, Müllertz A. Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state. Eur J Pharm Biopharm 2008; 69(2): 553-62.
[http://dx.doi.org/10.1016/j.ejpb.2007.12.020] [PMID: 18294829]
[16]
Rehman FU, Shah KU, Shah SU, Khan IU, Khan GM, Khan A. From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS). Expert Opin Drug Deliv 2017; 14(11): 1325-40.
[http://dx.doi.org/10.1080/17425247.2016.1218462] [PMID: 27485144]
[17]
Khan N, Craig DQM. The influence of drug incorporation on the structure and release properties of solid dispersions in lipid matrices. J Control Release 2003; 93(3): 355-68.
[http://dx.doi.org/10.1016/j.jconrel.2003.09.006] [PMID: 14644585]
[18]
Brubach JB, Ollivon M, Jannin V, et al. Structural and thermal characterization of mono-and diacyl polyoxyethylene glycol by infrared spectroscopy and X-ray diffraction coupled to differential calorimetry. J Phys Chem B 2004; 108(46): 17721-9.
[http://dx.doi.org/10.1021/jp047989m]
[19]
Xu S, Dai WG. Drug precipitation inhibitors in supersaturable formulations. Int J Pharm 2013; 453(1): 36-43.
[http://dx.doi.org/10.1016/j.ijpharm.2013.05.013] [PMID: 23680727]
[20]
Tang B, Cheng G, Gu JC, Xu CH. Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms. Drug Discov Today 2008; 13(13-14): 606-12.
[http://dx.doi.org/10.1016/j.drudis.2008.04.006] [PMID: 18598917]
[21]
Milović M, Djuriš J, Djekić L, Vasiljević D, Ibrić S. Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release. Int J Pharm 2012; 436(1-2): 58-65.
[http://dx.doi.org/10.1016/j.ijpharm.2012.06.032] [PMID: 22721847]

Rights & Permissions Print Cite
Article Metrics
42
2
Wayfinder Image
World Antimicrobial Awareness Week
© 2024 Bentham Science Publishers | Privacy Policy