Title:A Brief Review on Recent Developments in Diels-alder Reactions
Volume: 22
Issue: 1
Author(s): Manish Chaudhary, Shareef Shaik, Muskan Magan, Sharwan Hudda, Mukta Gupta, Gurvinder Singh and Pankaj Wadhwa*
Affiliation:
- School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, (Punjab), India
Keywords:
[4+2] Diels-Alder cycloaddition, intramolecular cycloaddition, asymmetric synthesis, diene, dienophile, catalytic systems.
Abstract: The [4+2] Diels-Alder cycloaddition has been widely used for the synthesis of six-member
scaffolds. In recent years, there have been significant developments in this area, including the
discovery and design of novel dienes and dienophiles with improved reactivity and selectivity.
These new building blocks can be used to develop diverse molecular structures with functional
group compatibility. Additionally, there is the use of catalytic systems and metal-mediated reactions
to enable asymmetric [4+2] cycloadditions, resulting in enantiomerically enriched products. Overall,
recent studies related to [4+2] Diels-Alder cycloaddition using numerous dienes, dienophiles,
and catalysts in different reaction conditions have significantly improved the efficiency, selectivity,
and versatility of the reaction, making it an increasingly important tool in the synthesis of complex
organic molecules as presented in this review. These advancements offer exciting possibilities for
the development of new methods and reagents for the construction of six-membered rings and the
synthesis of bioactive compounds.
