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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Empowering the Battle: Bioenhancers as Allies Against Cancer Drug Resistance

Author(s): Pratiksha Vasant Jadhav, Naga Jothi Prasath, Saurabh Ghannil Gajbhiye, Utkarsha Arun Rane, Tejas Girish Agnihotri, Shyam Sudhakar Gomte and Aakanchha Jain*

Volume 25, Issue 12, 2024

Published on: 10 November, 2023

Page: [1552 - 1563] Pages: 12

DOI: 10.2174/0113892010192038231107051715

Price: $65

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Abstract

Background: Drug resistance has been a great hindrance in the path of counteracting diseases like cancer and is driven by drugs misuse and overuse. In terms of cancer, resistance has been developed due to cellular changes, altered growth activation pathways, increased expression of efflux proteins, and changes in the local physiology of cancer (blood supply, tissue hydrodynamics, increased mutation rate/epigenetics, tumor cell heterogeneity). One of the approaches to address these challenges is the use of bioenhancers, which can overcome drug resistance, thereby improving bioavailability (BA).

Conclusion: Bioenhancers when combined with drugs can elicit pharmacological activity. They are generally combined with therapeutic agents at low doses, which increase the BA or therapeutic activity of active pharmaceutical ingredient (API). This review sheds light on the synthesis and classification of bio-enhancers. It also discusses different applications of bio-enhancers like piperine, ginger, quercetin, curcumin, etc. in the treatment of cancer. The review also presents some of the recent advancements in terms of nanocarriers for delivering API combined with bioenhancers.

Keywords: Drug resistance, bioavailability, bioenhancers, nanocarriers, cancer, therapeutic agents.

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