Title:Phytochemicals and their Potential Mechanisms against Insulin Resistance
Volume: 20
Issue: 7
Author(s): Pranay Wal*
Affiliation:
- PSIT-Pranveer Singh Institute of Technology (PHARMACY), NH19 Kanpur, Agra Highway, Bhauti Kanpur, Uttar
Pradesh 209305, India
Keywords:
Diabetes, insulin, glycogen, type 2 diabetes mellitus, phytoconstituents, quality of food, glucose transporter.
Abstract: Insulin's inception dates back to 1921 and was unveiled through a momentous revelation.
Diabetes is a dangerous, long-term disease in which the body fails to generate enough insulin
or utilize the insulin it creates adequately. This causes hyperglycemia, a state of high blood
sugar levels, which can even put a person into a coma if not managed. Activation of the insulin
receptor corresponds to two crucial metabolic functions, i.e., uptake of glucose and storage of
glycogen. Type 2 diabetes mellitus (T2DM) exists as one of the most challenging medical conditions
in the 21st century. The sedentary lifestyle and declining quality of food products have contributed
to the rapid development of metabolic disorders. Hence, there is an urgent need to lay
some reliable, significant molecules and modalities of treatment to combat and manage this epidemic.
In this review, we have made an attempt to identify and enlist the major phytoconstituents
along with the associated sources and existing mechanisms against insulin resistance. The conducted
study may offer potential sustainable solutions for developing and formulating scientifically
validated molecules and phytoconstituents as formulations for the management of this metabolic
disorder.
