A Review on Emerging Impact of Antitubercular Activity of 1,2,4-Triazole
Derivatives

Vedavathi      Rangaswamy; Umesh      Laddi
doi:10.2174/0122113525268198230921071016
Abstract

The present review aims to summarize the antitubercular profile of 1,2,4-triazole, one of the emerging entitled and most sought scaffold with a wide spectrum of biological and pharmacological activities. A systematic review of literature on ‘Heterocycles’, establishes the fact that 1,2,4-triazoles and their derivatives exhibit diverse activities. The 1,2,4-triazole core is found in therapeutically significant drugs and many new ones are in the pipeline. ‘Triazole pharmacophore’ has replaced the widely used ‘imidazole’ as ‘systemically integral azole’ by connecting synchronicity with serendipity. Triazoles are penetratingly studied as ‘diverse therapeutic agents’, due to the improved efficacy and reduced side effects. The extensive anthology of work carried out in the last two decades on 1,2,4-triazole moiety will provide imminent scope for the development of novel potential drugs having better efficacy, selectivity and reduced toxicity.
Keywords: 1, 2, 4-triazoles, triazole derivatives, Myzobacterium tuberculosis, H37Rv, antitubercular activity, pharmacological activities, antimicrobial activities, MIC, antibacterial, and antifungal.
Graphical Abstract

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DOI https://dx.doi.org/10.2174/0122113525268198230921071016	Print ISSN 2211-3525
Publisher Name Bentham Science Publisher	Online ISSN 2211-3533
Anti-Infective Agents

A Review on Emerging Impact of Antitubercular Activity of 1,2,4-Triazole Derivatives

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