![conference banner](/images/conference-banner.jpeg)
Abstract
Background: Patients undergoing radiotherapy are prone to radiation-induced gastrointestinal injury. Piperine is an alkaloid component in black pepper with a unique chemopreventive activity against oxidative stress-related damage in healthy tissues. The purpose of this study was to investigate the effects of piperine on intestinal damage.
Methods: In this study, mice were divided into eight groups: including the control, piperine (10, 25, and 50 mg/kg), radiation (6 Gy), and piperine+radiation (10, 25 and 50 mg/kg + 6 Gy) groups. The radioprotective effects of piperine were evaluated by biochemical (MDA, GSH, and PC) and histopathological assessments in colon tissues.
Results: The 10 mg/kg dose of piperine significantly reduced the levels of oxidative stress biomarkers compared to the group that received only radiation. In addition, pre-treatment with 10 mg/kg piperine diminished the histopathological changes like vascular congestion in the submucosa, while the dose of 50 mg/kg led to the infiltration of inflammatory cells.
Conclusion: Based on this study, it is concluded that piperine, at low dose, with its antioxidant properties, could reduce the colon damage caused by radiation.
Keywords: Ionizing radiation, piperine, radiation, colon injury, oxidative stress, radioprotective.
[http://dx.doi.org/10.1002/14651858.CD005037.pub2] [PMID: 16856073]
[http://dx.doi.org/10.3857/roj.2020.00213] [PMID: 33012151]
[http://dx.doi.org/10.1016/j.freeradbiomed.2020.10.012] [PMID: 33069855]
[http://dx.doi.org/10.1016/j.drudis.2007.07.017] [PMID: 17933679]
[http://dx.doi.org/10.1186/s12929-016-0306-8] [PMID: 27923354]
[http://dx.doi.org/10.3390/ijms21165804] [PMID: 32823530]
[http://dx.doi.org/10.2217/fon-2019-0416] [PMID: 31746639]
[http://dx.doi.org/10.1177/1534735418794885] [PMID: 30136590]
[http://dx.doi.org/10.3390/molecules24081582] [PMID: 31013611]
[http://dx.doi.org/10.1080/09553002.2021.1864047] [PMID: 33320758]
[http://dx.doi.org/10.1016/j.nucmedbio.2009.06.002] [PMID: 19720298]
[http://dx.doi.org/10.3857/roj.2015.33.2.66] [PMID: 26157675]
[http://dx.doi.org/10.1007/978-3-319-41334-1_8] [PMID: 27671817]
[http://dx.doi.org/10.1093/toxres/tfab001] [PMID: 33884168]
[http://dx.doi.org/10.3389/fphar.2021.669362] [PMID: 34122090]
[http://dx.doi.org/10.1016/j.jsps.2018.01.010] [PMID: 29556123]
[http://dx.doi.org/10.1002/ptr.6855] [PMID: 32929825]
[http://dx.doi.org/10.1078/0944-7113-00355] [PMID: 14971727]
[http://dx.doi.org/10.1080/19390211.2018.1481485] [PMID: 30299203]
[http://dx.doi.org/10.2174/0929867324666170523120656] [PMID: 28545378]
[http://dx.doi.org/10.1080/10408347.2019.1573656] [PMID: 30810335]
[http://dx.doi.org/10.1038/s41598-020-68574-2] [PMID: 32669593]
[http://dx.doi.org/10.21608/ejrsa.2016.1575]
[http://dx.doi.org/10.1177/0960327115622259] [PMID: 26699188]
[http://dx.doi.org/10.3109/09553002.2011.573439] [PMID: 21574903]
[http://dx.doi.org/10.52547/ijrr.20.2.24]
[http://dx.doi.org/10.1007/s10863-019-09820-9] [PMID: 31853753]
[http://dx.doi.org/10.1080/09553002.2018.1420926] [PMID: 29268056]
[http://dx.doi.org/10.1016/0003-2697(76)90527-3] [PMID: 942051]
[http://dx.doi.org/10.1016/S0076-6879(78)52032-6] [PMID: 672633]
[http://dx.doi.org/10.1016/j.jchromb.2015.11.052] [PMID: 26706659]
[http://dx.doi.org/10.3390/life11030195] [PMID: 33802553]
[http://dx.doi.org/10.1055/a-1019-9801] [PMID: 31627218]
[http://dx.doi.org/10.1016/0016-5085(86)90634-7] [PMID: 3015711]
[http://dx.doi.org/10.3109/03639045.2015.1052080] [PMID: 26072994]
[PMID: 34077015]
[http://dx.doi.org/10.1016/j.ejmp.2015.10.090] [PMID: 26526749]
[http://dx.doi.org/10.1155/2019/1309175] [PMID: 31178949]
[http://dx.doi.org/10.1186/s43088-022-00196-1] [PMID: 35127957]
[http://dx.doi.org/10.1016/S0009-8981(03)00003-2] [PMID: 12589963]
[http://dx.doi.org/10.1038/s41598-018-25586-3] [PMID: 29743497]
[http://dx.doi.org/10.3390/biology9090302] [PMID: 32967203]
[http://dx.doi.org/10.1177/0960327115584687] [PMID: 25926526]
![Wayfinder Image](/images/wayfinder.jpg)