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Mini-Review Article

缺氧诱导因子-1在膀胱癌中的作用

卷 24, 期 7, 2024

发表于: 24 August, 2023

页: [827 - 834] 页: 8

弟呕挨: 10.2174/1566524023666230720163448

open access plus

摘要

膀胱癌是世界范围内最常见的恶性肿瘤之一，严重危害人类健康。缺氧在BC的发展过程中起着至关重要的作用。缺氧诱导因子(Hypoxia-inducible factor, HIF)是低氧适应的关键转录因子，它调节多种基因的转录，包括炎症、血管生成和糖酵解代谢。近年来的研究表明HIF在BC多种生物学行为中的确切作用。更重要的是，一种新的靶向HIF-2的抗肿瘤药物已被用于治疗肾癌。然而，针对HIF-1在BC中的治疗尚未开发。在这篇综述中，我们讨论了HIF-1如何表达并影响BC的生长、转移和血管生成。同时，我们研究了几种HIF-1抑制剂，为靶向HIF-1提供了新的视角。

关键词: HIF-1，膀胱癌，葡萄糖代谢，血管生成，增殖，转移，耐药，治疗。

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